John McCain: A life in pictures

US Senator John McCain dies aged 81

He also had surgery for an intestinal infection in April.

The statement in part read, "Our family is immensely grateful for the support and kindness of all his caregivers over the previous year, and for the continuing outpouring of concern and affection from John's many friends and associates, and the many thousands of people who are keeping him in their prayers".

McCain, who had been receiving treatment in his home state of Arizona, was surrounded by his wife Cindy and his family during his final hours.

No further details were immediately provided.

"My heart is broken", she wrote.

McCain spent the past year undergoing cancer treatment, but his family said Friday that he would discontinue that treatment.

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McCain ran unsuccessfully for the Republican presidential nomination in 2000, then won it in 2008 before losing the general election to Obama.

Senator John McCain, the Vietnam war hero turned senator and presidential candidate, has died aged 81.

Trump's statement comes a little over a week after he failed to recognize McCain during a signing of the John S McCain National Defense Authorization Act, which lawmakers implemented to honor McCain's leadership of the Senate Armed Services Committee and his years of service in the Senate. People close to McCain told the White House in May that he didn't want Trump to attend his funeral and would rather have Vice President Mike Pence attend instead, a source confirmed to NBC News at the time.

"Flattery secures his friendship, criticism his enmity,"McCain said of Trump in his memoir, The Restless Wave, which was released in May". In a tweet Kasich shared that he and his wife "join the nation, and so many around the world, in mourning the death of Senator John McCain, an iconic American hero, patriot statesman without compare". "John McCain was many things - a proud graduate of the Naval Academy, a Senate colleague, a political opponent", he tweeted.

"In war and peace, John McCain dedicated himself to service & sacrifice for our country". But he also had a famous temper and rarely shied away from a fight.

McCain died a year after he was diagnosed with brain cancer.

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Trump and McCain's bad blood stems back to June 2015 when Trump announced he was running for president and called Mexican immigrants "rapists" and drug runners during a speech. Saxby Chambliss (R-GA), who admitted "I had my differences with John", but like many other colleagues, they saw a Senator who cut a unique path through the Congress.

After Trump became president, McCain blasted what he called the president's attempts to undermine the free press and rule of law, and lamented the "half-baked, spurious nationalism" of the Trump era.

Known for his combustible temper, he accused the 45th president of "naivete", "egotism" and of sympathising with autocrats.

John Sidney McCain, III followed family tradition by serving in the United States Navy. He was elected to Congress in 1982 and to the Senate four years later, replacing the retired Barry Goldwater.

McCain, 81, died at his ranch near Sedona, Arizona, his office announced on Sunday.

Barack and Michelle Obama: "John McCain and I were members of different generations, came from completely different backgrounds, and competed at the highest level of politics". But the choice backfired as her political inexperience and shaky performances in media interviews raised concerns about her qualifications. Barack Obama. "He's an Arab", she said, implying he was not an American. McCain reached the pinnacle of his political career as the Republican Presidential Nominee in 2008. "I ejected", McCain recounted to C-SPAN in 2003.

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The force of the ejection was so violent, McCain broke his right leg and both arms.

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