Male infertility among many side effects linked to ibuprofen

Male infertility among many side effects linked to ibuprofen

The researchers determined that young men given ibuprofen developed compensated hypogonadism, a condition that occurs when males have normal levels of testosterone, but higher levels of luteinizing hormone (LH), a substance that stimulates the production of testosterone.

Researchers even tested ibuprofen on "bits of human testes" collected from organ donors and saw the same result: The drug hampered testosterone output. The men were then divided into two groups, 14 in an ibuprofen group and 17 in a placebo group.

Men who take ibuprofen for longer than the bottle advises could be risking their fertility, according to a new study.

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The study, published this week in the journal Proceedings of the National Academy of Sciences (PNAS), monitored 31 healthy white men aged 18 to 35. Sold under the brand names Advil or Motrin, ibuprofen is a member of the class of drugs known as NSAIDS (nonsteroidal anti-inflammatory drugs).

The French National Institute of Health and Medical Research's Bernard Jegou, a senior author of the study, said that there is no problem in taking ibuprofen for short-term pain relief. This is because the pituitary gland at the base of the brain had ramped up levels of another hormone that drives the production of extra testosterone. The ratio of these hormones to testosterone dropped, causing compensated hypogonadism.

While it is important to note that this was a small study and more research is clearly called for, the fact that ibuprofen is so widely and casually used by so many men makes it a point of concern, particularly for those who intend to start a family.

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Ibuprofen has also been linked to increased risk of heart attacks or stroke in those who take it long term. But, don't worry, if you just want to tiresome the pain of a minor ankle sprain for a week or two, Jégou says, "it is sure that these effects are reversible". However, it's uncertain if the effects produced by long-term usage at these doses could be reversed.

Erma Z. Drobnis, an associate professional practice professor of reproductive medicine and fertility at the University of Missouri, said the effects that drugs have on male fertility are rarely evaluated before marketing.

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